Differential Pathophysiology of Bacterial Translocation After Thermal Injury and Sepsis
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چکیده
منابع مشابه
Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge.
Burn injury and sepsis produce acute gastrointestinal derangements that may predispose patients to bacterial translocation. We studied the effects of enalapril, an angiotensin converting enzyme inhibitor (ACEI), on gastrointestinal anatomic alterations, bacterial translocation, and related mortality during gut-derived sepsis in burned mice that had received a prior bacterial challenge. BALB/c m...
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Cutaneous injury by thermal burns in experimental animals produces a highly reproducible acute model for studying the barrier function of the intestine wherein the magnitude of microbial translocation is directly associated with the extent of injury. Translocation after burn occurs throughout the intestinal tract with extreme rapidity, reaches an early peak within hours, and then has a less int...
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background: multi drug resistant (mdr) pseudomonas and acinetobacter species are defined as resistant to at least three classes of antibiotics. most studies have demonstrated that mdr gram negative infections convey increased mortality and morbidity. case: an 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (tbsa). discussion: ...
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Few pathogens cause sepsis. The majority of sepsis causing bacteria is facultative anaerobes. This type of respiration is the most flexible and it facilitates pathogen survival, proliferation and dissemination in human tissues and blood. Other conditions for causing sepsis are thick slime layer and capsule, as well as production of antioxidant enzymes and substances (superoxide dismutase (SOD),...
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Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating the host’s immune system. Macrophages require surface receptors to present pathogenic molecule to Toll-like receptors (TLRs) to be activated and release proinflammatory cytokines such as tumour necrosis factor (T...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1991
ISSN: 0003-4932
DOI: 10.1097/00000658-199107000-00005